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By altering the AMPK/NLRP3/TGF- signaling, luteolin treatment in diabetic nephropathy led to the mitigation of renal fibrosis by upregulation of phosphorylated AMPK (p-AMPK) and the downregulation of pro-inflammatory and fibrotic markers like p-NF-B, NLRP3, Collagen I, TGF-1, and -SMA [122]

10.1016/j.cbi.2008.10.050 [DOI] [PubMed] [Google Scholar] Staab C

Savary et al., 2021

Analogously, KRAS inhibitors (Sotorasib) targeting the G12C mutation and eprenetapopt (APR-246), a novel drug for Tp53 -mutant MDS and AML, both are representatives of this molecules

Researchers designing combination protocols typically run controls with each compound in isolation alongside the combination arms to distinguish additive from synergistic effects and to identify which compound is driving each observed outcome