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Although silicone rubber possesses excellent stability, the implant is still considered to be a foreign object in vivo and must be removed when it expires [44]

Curiously, a p53 mutant that cannot be acetylated on certain lysine residues (3KR mutant) loses its ability to induce cell cycle arrest, senescence, or apoptosis, yet is still capable of suppressing tumor formation in vivo (Li et al., 2012)

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And it increases glycosaminoglycan synthesis, improving skin hydration and skin elasticity at the structural level