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4.1 Advanced glycation end products AGEs play multifaceted roles in the pathogenesis of PCOS (7577)

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[24] At chemical synapses, glutamate is stored in vesicles

Moreover, agrin-treated pericytes exhibited elevated levels of ROS and Fe 2+ , along with reduced expression of GPX4 and FTH1, thereby promoting ferroptosis, suppressing pericyte proliferation, and compromising blood-brain barrier function

For example, selecting an efficient delivery vector, ensuring it reaches a sufficient number of cells, preventing the newly implanted gene from becoming inactive, and managing any adverse effects from the added MECP2