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Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

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133 Further, in vitro studies using human cell lines have shown that acetaminophen can cause an immediate, reversible, dose-dependent loss of oxygen uptake followed by a slow, irreversible, dose-independent death and have suggested mechanisms by which acetaminophen may cause toxicity in tissues other than the liver

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