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No local or systemic adverse events were observed during desensitization

Increased pressure in the portal venous system results in portal hypertension

On the other hand, many authors either did not notice a relationship between the level of vitamin E and the occurrence of the disease [28,29,30] or even observed a reduced concentration of this microelement in serum [31]

Many of the nature-derived small molecules exhibit promises in Nrf2 modulation, which still requires further investigations for optimization and clinical translation

Given the significant role of ferroptosis in tumor growth, invasion, and metastasis, interventions that interfere with tumor cell iron metabolism and induce ferroptosis have the potential to effectively suppress tumor progression and dissemination, thereby improving treatment responses and prognoses, ultimately leading to better survival rates and quality of life for patients [312, 313]