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Some practitioners employ intermediate dose increases, such as escalating by 0.25 mg increments rather than doubling doses, to improve tolerance in sensitive patients

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It shows how the solvation-shell waters are structured at different ion separations

(For more information on titrations and the equivalence point, see Chapter 4 "Reactions in Aqueous Solution", Section 4.9 "Quantitative Analysis Using Titrations".) For the titration of a monoprotic strong acid (HCl) with a monobasic strong base (NaOH), we can calculate the volume of base needed to reach the equivalence point from the following relationship: Equation 16.50 If 0.20 M NaOH is added to 50.0 mL of a 0.10 M solution of HCl, we solve for V b : Figure 16.18 The Titration of (a) a Strong Acid with a Strong Base and (b) a Strong Base with a Strong Acid (a) As 0.20 M NaOH is slowly added to 50.0 mL of 0.10 M HCl, the pH increases slowly at first, then increases very rapidly as the equivalence point is approached, and finally increases slowly once more