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The first few weeks after quitting may be the hardest, as alcohol withdrawal symptoms set in

FDA asked Medline Industries to respond to its warning letter within 15 business days and noted that since the December 2025 inspection, the agency has updated its Quality System (QS) regulation to the Quality Management System Regulation (QMSR) to harmonize with international regulatory standards

PLoS ONE 8 , e64570 (2013)

Proc Natl Acad Sci USA 110(8):31073112

However, due to a small number of animals (n = 2 per group), this was not statistically significant