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It was only recognized in the late 1980s that desensitization of insulin secretion, which describes a state of decreased secretory responsiveness of -cell to the glucose stimuli, is a pathophysiological phenomenon of -cell function and not just an in vitro artifact 30
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In other words, if the average person has a 50% chance of developing insulin resistance then patients with thyroid disease probably have about a 70% chance of having the same condition
10.1007/s12602-019-09613-x 108
Furthermore, SIRT1 deficiency mice showed typical pre-eclampsia-like performances, which can be reversed via direct SIRT1 supplement or SIRT1 agonist treatment
