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6, 22 The mammalian tyrosine catabolic pathway was described in the early 1950s by Edwards and Knox

While platelets are best known for their role in blood clotting, they also contain hundreds of specialized proteins called growth factors

Similarly, it is difficult to imagine how loss of the extracellular Sod3 can be protective both in an A toxicity model (Favrin et al., 2013) and to H 2 O 2 and ROS generators like PQ (Blackney et al., 2014) unless it also serves to regulate some cellular functions in response to ROS levels rather than protect from superoxide damage