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- If taking medications indicated for control of AD symptoms, on stable doses for at least 8 weeks prior to screening Exclusion criteria - Any history of bipolar affective disorder - A medical condition, other than AD, that may contribute to the individuals cognitive impairment - Stroke or transient ischemic attack in the past 12 months - Clinically significant unstable psychiatric condition in the past 6 months - Inability to swallow oral medications - Other medical conditions which the investigator deems would limit the individuals life expectancy to less than 6 months - Concurrent use of anti-depressant medication - Participation in another interventional clinical trial, or intake of another investigations drug within 4 weeks or 5 half-lives (whichever is longer) Study Estimands Primary estimand 1

133 This process is primarily regulated by PGC-1 (PPAR- coactivator-1), a key regulator that activates nuclear respiratory factors NRF-1 and NRF-2, as well as oestrogen-related receptor- (ERR-)

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Dopaminergic System Interaction : Studies suggest potential interactions with the dopaminergic system, which may explain some of the observed effects in neurological research models

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