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In aged skeletal muscle models, NNMT inhibitor treatment increased proliferating/active muscle stem cells by 60-75% following injury, myofiber cross-sectional area increased 1.8-fold at one week post-injury with high-dose treatment, and peak torque of injured muscle increased by 67% compared to control (p = 0.033), with no untoward systemic toxicity observed in plasma chemistry markers (Neelakantan et al., 2019)

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[DOI] [PubMed] [Google Scholar] 141.Wang, H., Li, S., Zhang, G., Wu, H

Treatment with NNMT inhibitors rescues these age-related deficits by restoring NAD+ availability and supporting metabolic reprogramming during myogenic differentiation