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This paradoxical effect could be dose-dependent, as most of the anti-inflammatory effects in vitro are carried out at 5 or 10 M, while higher doses are known to increase ROS and even inhibit ROS-scavenging enzymes such as GR and GPx activity in cancer cells [371]
Peterson LW, Artis D
Doxorubicin was selected as a training compound for three reasons: i) the quinone moiety, present in doxorubicin, is acknowledged as a notorious redox cycler
[DOI] [PubMed] [Google Scholar] 390.Tiidus PM, Pushkarenko J, Houston ME
doi: 10.1007/s12012-024-09852-7
