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Duration of treatment depends on the underlying cause: Lifelong therapy is required for pernicious anaemia or irreversible malabsorption (e.g., after gastrectomy) For dietary deficiency without malabsorption, treatment may be reviewed once deficiency is corrected and neurological symptoms have resolved Oral B12 supplementation is generally not recommended for patients with neurological symptoms, particularly when pernicious anaemia is the cause

Biochem Pharmacol 64:104956, PMID: 12213604 Poole LB, Karplus PA, Claiborne A (2004) Protein sulfenic acids in redox signaling

doi: 10.1016/j.ymgme.2020.07.010

T.SinghS.ZenaM.WaltersR.FriedmanK.et al (2018)

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