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Salvianolic acid C, the active ingredient of Salvia miltiorrhiza , upregulates PGC1, reduces the lactic acid concentration in renal tissues or cells, increases PCK1 expression, and inhibit RF by regulating renal gluconeogenesis mediated by glucose and lipid metabolism [175]

This cell damage can lead to apoptosis, necrosis, teratogenesis, or carcinogenesis

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(76) evaluated the effect of combined vitamin E and omega-3 supplementation on PCOS patients and found that the combined application of vitamin E and omega-3 could significantly reduce the expression of the IL-8 and TNF- genes and upregulate the expression of peroxisome proliferator-activated receptor- (PPAR-)