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The timeline for noticeable improvements can vary depending on factors such as wound severity, overall health, and treatment consistency

Decreased blood and mucosal levels of antioxidants such as vitamins C, E and -carotene have been reported in CD patients (7)

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As mentioned before, a critical limitation of these strategies lies in the degeneracy of dominant nociceptor subtypes that may dynamically shift following nerve injury or over time, diminishing the efficacy of highly selective monotherapies [361, 362]

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