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2013, and FDA's December 2024 review lists the same trial set

[PubMed] [Google Scholar] 43.Karadag AS, Tutal E, Ertugrul DT, Akin KO, Effect of isotretinoin treatment on plasma holotranscobalamin, vitamin B12, folic acid, and homocysteine levels: noncontrolled study

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We used a Mendelian randomization design to test whether this relation might be causal

If you feel nauseous after having the vitamin, you may need to eat it with food and avoid exercising right after
