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Aging Cell 18 , e12865 (2019)

One difference between their model and the one reported here is that deletion of Gclc is induced in hepatocytes of adult mice (which are slowly proliferating), compared to theirs, where deletion of Gclc occurred in hepatocytes of growing animals (which are rapidly proliferating)

The appeal is obviousstronger, faster, more whole body effectsbut the reality is much less defined

These compounds, when produced in larger quantities under stress, can lead to extensive damage of DNA, proteins, and plasma/organelle membranes in the cell (Olinski et al., 1992

[DOI] [PMC free article] [PubMed] [Google Scholar] 35.Morgan M.J., Liu Z.G