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It interacts with SARS-CoV-2 as well as IAV and is reported in three CRISPR-Cas9 studies as a relevant host factor during SARS-CoV-2 infection 32,33,34

Roles of Mitochondrial Serine Hydroxymethyltransferase 2 (SHMT2) in Human Carcinogenesis
[DOI] [PubMed] [Google Scholar] 51.Kadoch C, Crabtree GR

However, commonly used ferroptosis modulators are often associated with significant side effects, including pulmonary toxicity (Parry et al., 2002), liver damage, and neurotoxic effects (Zaafar et al., 2024)

11 Effect of Dihexa and HGF treatment on the frequency of mEPSCs in dissociated hippocampal neurons
