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J Pharmacol Exp Ther 265:12391244 McCarty MF, DiNicolantonio JJ (2020) Nutraceuticals have potential for boosting the type 1 interferon response to RNA viruses including influenza and coronavirus

2018;12(5):OE01OE08

These macrophages produce substantial pro-inflammatory mediators, drive local inflammation, and enhance effector T cell functions ( 4.3 M2 macrophages in UC Polarization of M2 macrophages is induced by the cytokines IL-4 and IL-13

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15 Being a powerful antioxidant, glutathione plays a critical role in several metabolic pathways: DNA and protein synthesis, amino acid transport, enzyme activation, immune system function, scavenging free radicals eg hydrogen peroxide, cofactor in Phase I cytochrome P450 enzyme-mediated detoxification, amino acid translocation across cell membranes, detoxification of xenobiotics, maintenance of sulfhydryl groups of proteins, mitochondrial function and maintenance of mitochondrial DNA, catalysis of exchange reactions and many more