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The mechanism cited most often in the preclinical literature is upregulation of vascular endothelial growth factor signaling (VEGFR2) alongside modulation of the nitric-oxide system

We have used this model to study the role of endogenous GSH in sepsis

Mar 2010;6(1):74-5

699 Apigenin efficiently inhibits the interaction of hnRNP A1 and A2 with EV-A71 RNA thereby inhibits EV-A71 RNA translation