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In our model we use a V max of 1100 M/hr, a K m of 3000 M, and a Hill coefficient of 3

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An anti-PCSK9 antibody reduces LDL-cholesterol on top of a statin and suppresses hepatocyte SREBP-regulated genes
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This leads to a gradual loss of vision, which can develop from visual disturbances such as spots and fogginess, to an almost complete loss of sight