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Melatonin has been reported to bind KEAP1, thereby disrupting this interaction and permitting NRF2 to translocate to the nucleus where it can activate antioxidant response element (ARE)-driven gene expression (25, 41, 62, 63)

Acknowledgements This work was supported by the Research Fund of Ghent University, Belgium, grant BOF08/GOA/004 and BOF14/GOA/010 and Fonds Wetenschappelijk Onderzoek Vlaanderen (grant FWO14/PDO/067)

GPx comprises at least eight different members in humans, labeled GPx1 to GPx8 (Floh and Brigelius-Floh, 2011)

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Jennings, Amy, et al