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These two pathways cooperate in several ways: IFN-I generated by cGAS-STING heightens NLRP3 sensitivity, and NLRP3-dependent IL-1 upregulates cGAS via NF-KB, creating a positive-feedback loop

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Mechanistic insights into spontaneous mutagenesis driven by NER deficiency We explore the role of NER in shaping the landscape of the novel SBS-PolkKO mutations and also uncover interesting mechanistic insights into cancer mutational signatures linked to NER deficiency alone (Fig

Dupilumab decreases mast cells in these diseases

However, when injection pain or inflammation lasts longer than expectedor begins to worsenit may signal something more serious