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It has to distinguished that the replacement therapy should be only undertaken to restore the physiological levels, never to exceed physiological ranges
T.Prez-SanchezG.Becerril-VillanuevaE.Alvarez-HerreraS.Mendieta-CabreraD.et al
Biomedicine pharmacother = Biomed pharmacotherapie (2020) 129:110282
FK866 was again administered at a low dose (0.5 mg/Kg) to aged mouse models over four weeks, leading to significant improvements in cognitive function and locomotor activity
