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Two clinical trials investigated the benefits of B12 in non-diabetic neuropathy

The NAD+ boost is blunted by 4050%, and sirtuin activation is minimal because substrate availability favors glucose oxidation over fat

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Vision disturbances : B12 deficiency may cause vision disturbances, possibly due to damage to the optic nerve (29) Because vitamin B12 deficiency symptoms arent specific to the condition, it may go undetected or get misdiagnosed

Scientific research Scientific literature offers numerous examples from which it can be concluded that treatment with high dose B12 up to very high serum values is no cause for concern