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BPC 157-rats Specifically, BPC 157, 10 g/kg, 10 ng/kg regimens, exhibited a consistent counteracting effect (i.e., markedly reduced the bleeding time, blood loss and also counteracted: acute thrombocytopenia in rats with amputation only, in heparin-rats or warfarin-rats), prolonged APTT-, TT- values (heparin-rats), but not PT-values (warfarin-rats))

Importantly, the circadian interplay between PER2 and p53 forms a regulatory feedback loop in which p53 suppresses PER2 expression, while PER2 stabilizes p53 by inhibiting MDM2-dependent ubiquitination, linking circadian rhythm to cellular stress responses and tumor suppression (Gotoh et al., 2015