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Another group independently also concluded that disability progression and brain atrophy occur earlier than in the classical secondary progressive stage, with many relapsing patients exhibiting insidious progression without clinical or radiographic evidence of inflammatory disease activity, coining the term silent progression (Cree et al., 2019)

In the terminal ileum, the cobalamin-intrinsic factor complex is specifically recognized by the cubam receptor on the apical surface of enterocytes, triggering receptor-mediated endocytosis

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Animals The animals had free access to food and drinking water before the experiments

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