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FIGURE 2 5.2 Clinical application of intranasally delivered drugs Although IN delivery of iron chelators remains in the early preclinical stages and has not yet entered clinical trials, the broader field of IN route has gained increasing attention over the past decade, as evidenced by a notable rise in related clinical studies

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In the non-canonical pathway, LOS on OMVs or intracellular bacteria is first recognized by guanylate-binding proteins (GBPs) that recruit caspase-4 (murine caspase-11) (Vanaja et al., 2016

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