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B12 shots lose their effect over one to two weeks
doi: 10.1016/0026-0495(94)90097-3
It also increases collagen III for tissue flexibility and drives collagen IV production up by a remarkable 25.4-fold when combined with hyaluronic acid

Effects of Pycnogenol on endothelial function in patients with stable coronary artery disease: A double-blind, randomized, placebo-controlled, cross-over study
We looked at curcumin in this study and compared it to deferiprone, a wellknown iron chelating agent, as the ligand control
