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Concurrently, the imbalance characterized by reduced beneficial bacteria such as Bifidobacterium and Lactobacillus , and proliferation of opportunistic pathogenic bacteria such as Enterobacteriaceae and Streptococcus significantly disrupts gut immune homeostasis, promoting chronic low-grade inflammation (Liu Y

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The results reported by Gonalves are consistent with those obtained by Huang, that inhibiting autophagy enhances the effect of therapeutic agents, such as TMZ