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Non-targeted LC-MS/MS (liquid chromatography-tandem mass spectrometry) analysis was performed with an Ultimate 3000 HPLC system (Thermo Fisher Scientific) coupled to a Q Exactive Focus mass spectrometer (Thermo Fisher Scientific)
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Endothelial cell dysfunction results in ECM metabolism disorders, VSMC apoptosis, aortic wall thinning, and then aortic aneurysms and dissection
