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In the pathological progression of PD, the inflammatory response initiated by aberrant microglial activation plays a crucial role in the degeneration of dopaminergic neurons

Rapid cell death is preceded by amyloid plaque-mediated oxidative stress

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-Glutamyl transpeptidase catalyses the extracellular detoxification of cisplatin in a human cell line derived from the proximal convoluted tubule of the kidney

Zinc supports this interplay by maintaining antioxidant enzymes, including peroxisomal Cu/Zn-SOD and mitochondrial SOD1, and by regulating redox signaling pathways 97