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Foldvari and Elsabahy, 2011

These mechanisms would be the plausible explanation for the cause of 1,2-DCP-related cholangiocarcinoma, especially in extrahepatic cases that are proposed to arise from the biliary epithelium and peribiliary gland 43

at low physiological concentrations, zinc serves a twofold function of both neutralizing the negative charge density at the C terminal of -synuclein and assists other chaperones which work in a concerted manner to prevent aggregation of -synuclein, whereas at higher concentrations, zinc promotes fibrillation by binding to His50 at the N terminus and lowering its pK a , much like that observed in case of iron (Valiente-Gabioud et al., 2012)

Microbiol 9 , 395 (2018)

Clinical studies indicate that polyphenol-rich diets, such as the Mediterranean diet, improve metabolic syndrome parameters by lowering inflammatory markers, enhancing lipid profiles, and improving insulin sensitivity