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The total activity of ADH was also significantly elevated in cancer in comparison with normal tissue
For this reason, individuals with pre-existing skin disorders or impaired skin integrity should avoid prolonged exposure to topical applications or water with markedly elevated pH (72, 73)
Conjugated metabolites that are pharmacologically active are not often successfully developed into drugs, whereas there are many examples of active Phase I metabolites that become drugs
Naito et al
J Chem Inf Model 61(8):38918 Emadi A, Jones RJ, Brodsky RA (2009) Cyclophosphamide and cancer: golden anniversary
