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System Xc - -related cystine transportation is important to maintain intracellular cysteine levels as it is a critical precursor for glutathione (GSH) synthesis [61] serving as a co-factor for glutathione peroxidase 4 (GPX4) to detoxify lipid peroxides [12]

One main limiting factor for successful IS therapeutic intervention is stroke-induced bloodbrain barrier (BBB) damage, particularly over tight junction proteins (TJs)

Science 346 , 15251528 (2014)

As research continues to evolve, the nuances between these forms of glutathione become increasingly relevant for those seeking to optimize their antioxidant intake and overall health

Monocytes and macrophages are increasingly recognized as key contributors to disease pathogenesis (85)