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This intervention results in enhanced tryptophan metabolite production and a reduction in liver injury and inflammation following microbial transplantation [210]

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The l-methionine vs sam-e pathway analysis demonstrates that SAM-e bypasses the rate-limiting steps and cofactor dependencies that can restrict L-methionines therapeutic effectiveness, particularly in individuals with genetic variations affecting methionine metabolism

doi:10.1542/peds.2006-1347

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