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These individuals cannot efficiently convert cyanocobalamin to the active methylcobalamin form, which is required for methionine synthase activity in the methyl donor cycle
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TOR signaling TOR is a mechanistic target of rapamycin or mammalian target of rapamycin, and a serine/threonine kinase that regulates cell growth, proliferation, motility and survival, as well as protein synthesis, autophagy and transcription

Unscheduled stoppages consume 45 minutes of line time, compounding to a 6-8% annual throughput reduction across three-shift CMO operations