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CHLOROPLASTS AND PEROXISOMES Compartment-specific changes in glutathione contents in chloroplasts and peroxisomes seem to be involved in the fine tuning of plant defense against pathogens
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In humans, a primary source of ROS is the metabolic byproduct end of the respiratory chain located in the inner mitochondrial membrane
Results Neuronal GCLC knockout leads to brain atrophy accompanied by neuronal cell death To examine how the declines in GCLC and glutathione might affect brain homeostasis, we prepared GCLC floxed X CaMKII-Cre (GCLC-KO) mice whose GCLC expression is deleted in calcium/calmodulin-dependent protein kinase II (CaMKII)-positive neurons
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