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NETs induce Fundc1 phosphorylation of endothelial cells, inhibit mitochondrial autophagy and lead to mitochondrial ROS overproduction and lipid peroxidation, thus inducing endothelial cell ferroptosis and microvascular dysfunction

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Furthermore, the GLP-1 secretion, which was inhibited by pasireotide in response to a high glucose level with L-glutamine and sodium butyrate stimulation, was significantly lower than the basal GLP-1 secretion in the low-glucose (0.1 mM) state in GLUTag cells (Fig