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Additionally, a randomized, double-blind, placebo-controlled trial in 2,588 healthy older adults with mild hyperhomocysteinemia found that daily supplementation with 500 g of vitamin B 12 and 400 g of folic acid for two years reduced blood homocysteine concentrations but had no benefit on depressive symptoms in those with or without depressive symptoms at baseline (110)

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Injections are often neededdaily/ alternate days at first, then weekly or monthly

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The Facts About Vitamin B12 Vitamin B12 is a water-soluble vitamin that plays an important role in brain function and red blood cell production