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Some weight loss clinics include B12 injections as part of their weight management programs, often in combination with other treatments such as a healthy diet and exercise

No human clinical trials of Dihexa itself have been published in peer-reviewed literature as of 2026

The endomorphins have been identified by immunochemistry in the outer layers of the spinal cord dorsal horns, nucleus ambiguous, spinal trigeminal nucleus, NAc, thalamic nuclei, septum, hypothalamus, amygdala, locus coeruleus, and PAG

Supplementary information Acknowledgements This work was supported by Chang Gung Memorial Hospital [CMRPG391311, CMRPG3A1131, CMRPG3H0611 and Grants CIRPD1D0071-3

Results vary by individual, and no specific outcomes are guaranteed