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BCMA is used as a biomarker for Multiple myeloma (MM)

Consistently, a complementary strategy showed that in aged mice, where IGF-I levels are decreased, cardiac overexpression of IGF-I significantly improved cardiomyocyte contractile function[283], attenuating oxidative stress-mediated protein damage, normalizing Ca 2+ homeostasis, reversing age-related alterations in the expression of pro-apoptotic proteins, and decreasing the apoptosis rate[284]

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Its key physiological functions include: Nitrogen transport between tissues Acid-base regulation Supporting gluconeogenesis Serving as a precursor to nucleotide bases Boosting the antioxidant glutathione (Cruzat et al., 2018, Nutrients ) Glutamines Role in Muscle Growth and Recovery L-Glutamine plays a powerful role as a signaling molecule in stimulating anabolic pathways such as muscle protein synthesis and cell growth , while inhibiting catabolic pathways including protein degradation and apoptosis (Newsholme et al., 2003, The Journal of Nutrition )