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A new era was dawning.

Alterations in mitochondrial function and dynamics are frequently observed in cancer cells, most commonly metabolic reprogramming with increased aerobic glycolysis and reduced oxidative phosphorylation (OXPHOS) (29)

A study suggested that WZB may enhance toxic effects on the NSCLC cell line H460 by limiting glycolysis (18)

Furthermore, FGF21, another hepatokine modulated by exercise, has been shown to increase hippocampal synaptic plasticity, reduce systemic inflammation and neuronal cell death, and enhance cognitive function [131]

however, its expression progressively declines during the transition from benign nevi to dysplastic nevi and ultimately to melanoma