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In Vivo Deletion of -Cell Drp1 Impairs Insulin Secretion Without Affecting Islet Oxygen Consumption

10.3389/fnagi.2017.00078 54 LeaoA

416 Liver-specific CDK5RAP3 KO significantly delays liver regeneration and reduces glycogen synthesis

Animal Toxicology Studies Animal toxicology studies tested doses from 0.0027 mg/lb to 9.1 mg/lb via intraperitoneal, intramuscular, intravenous, and oral routes for up to 6 weeks, finding: No acute toxic or lethal dose No gross or histologic toxicity in major organs No hepatotoxicity or nephrotoxicity Negative Ames test (no mutagenicity) Negative chromosomal aberration tests (no genotoxicity) No teratogenicity in rat pregnancy studies No local injection site irritation The LD1 (minimum lethal dose) could not be achieved despite aggressive testing

The majority of individuals booking an intravenous Myers Cocktail injection do not have acute illnesses