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Multicenter intervention studies are currently testing the effects of supplemental IGF-1/IGFBP3 in extremely preterm infants on respiratory outcomes and ROP (ClinicalTrials.gov Identifiers NCT03253263 and NCT01096784, respectively

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doi: 10.1016/S0140-6736(14)61393-3 4 ObesoJAStamelouMGoetzCGPoeweWLangAEWeintraubDet al

Early trial data showed approximately 13% weight loss at 12 weeks, a pace that projects to potentially 25-30%+ at full treatment duration
