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Using NFE2L2 knockout mice, it has been demonstrated that NFE2L2 is essential for mitobiogenesis

More serious but less common risks include pancreatitis (characterized by severe abdominal pain that may radiate to the back), gallbladder disease, and acute kidney injury from volume depletion

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Although they yield great clinical outcomes, they are also associated with serious adverse effects due to their complete blockade of DAT [39]
