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The sulfonylureas have been used in the US for nearly 50 years

Metabolic diseases As society has developed and the global population has aged, aging and metabolic diseases, including obesity, type 2 diabetes mellitus (T2DM), hyperglycemia, dyslipidemia, insulin resistance (IR), and NAFLD, have become major public health concerns

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In addition to improved brain energy metabolism, ketogenic diets are associated with alteration in AD CSF biomarkers (Neth et al., 2020)
