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Plegridy is generally well tolerated, with adverse effects similar to conventional interferons, including immunosuppression, flu-like symptoms, injection-site reactions, and mild laboratory abnormalities

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For example, thrombocytopenia was mainly observed among vaccinees who received the ChAdOx1 adenoviral-vector-DNA (AstraZeneca) vaccine (145, 146) and cutaneous vasculitis was observed mainly in those receiving ChAdOx1 (147) or the BNT162b2 mRNA (Pfizer-BioNTech) vaccine (148, 149) (reviewed in (150))