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Additionally, L-carnitine upregulates peroxisome proliferator-activated receptor (PPAR) (18), a key regulator in the liver inflammatory response and oxidative stress (19,20), which has been found to be involved in regulating the expression of CPT I (21)

According to the OSL risk assessment approach, intakes up to 2000 mg/day of LC equivalents for chronic supplementation provide high evidence of safety, and this amount is designated as the observed safe level (OSL)

A metabolomic analysis conducted by Ruiz et al

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