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To achieve equivalent plasma concentrations, oral doses would need to be 35 times higher than injection doses approximately 150250mg methionine daily which increases gastrointestinal side effects like nausea and diarrhea
Rangaraju, S., Solis, G
McGough et al ., 2005[69])
Pucci S, Zonetti MJ, Fisco T, Polidoro C, Bocchinfuso G, Palleschi A et al
This is consistent with the notion that the alternative pathway that short circuits the citric acid cycle is upregulated
